Investigators say the lethal mix lived up to its name, nearly killing a man in the Bronx in September.
NYC recently invested $70 million in the anti-opioid policing.
The DEA said if the seized drugs are all fentanyl, then "This seizure alone contains enough potency to kill half of the population of New York City."
Officials say the drugs could have caused up to 7 million overdoses.
"The aesthetic is to be natural and really blend in, but also to stand out to those who know what it is and need to know what it is."
Imodium is the brand name for a medication called loperamide, which is an opioid.
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