One of the biggest problems the Giants face this season is their inability to run the ball. They average 3.2 yards per rush, second-worst in the NFL. Last year they averaged 4.6 yards per rush. And before you blame the backs, it's worth noting that Eli Manning has already been sacked 14 times after only being sacked 16 times last year. Clearly, the Giants miss guys like Seubert and O'Hara along the offensive line. But, if there was a week for the rushing game to get on track, this is it.

Buffalo may be 4-1, but they allow 5.5 yards per rushing attempt, worst in the league. The Giants probably won’t have Brandon Jacobs, but Ahmad Bradshaw can certainly handle the bulk of the running game on his own.

The Giants have several other injuries that could prove significant. Justin Tuck and Chris Snee will join Brandon Jacobs on the sideline while David Baas is questionable. There are a lot of reasons to pick against the Giants in this one, but the pick here is New York in a squeaker.