Last season at Giants Stadium, Mark Sanchez played his worst game of his career against the Bills. He threw five interceptions and the Jets lost in overtime. The Jets did manage to win the game "at" Buffalo -- it was played in Toronto -- but the Bills have a recent history of success against the Jets despite a recent history of stinking. This year, the Jets are good enough and the Bills are bad enough that it shouldn't be a problem.
The Bills have already switched quarterbacks -- to Harvard product and former seventh-round pick Ryan Fitzpatrick -- and don't have any threatening weapons. They did put up 30 points against New England last week, but the Patriots' secondary is atrocious. (Also, seven of those points came off a kick return.)
As for the Jets, they held off a Dolphins charge on Sunday night in Miami. They could be caught looking ahead to Brett Favre and the Vikings a week from Monday, but they don't need all their eyes on this one. Dustin Keller, LaDainian Tomlinson and Sanchez are all among the offensive stars. So is Braylon Edwards, even if he hasn't been a star off the field. Expect an easy win, even on the road.