This post at dollarshort.org rang true for me...for a moment:
Once, long ago, after receiving a particularly personal, dramatic, too-much-information type of email from an acquaintance, I was about 87% tempted to reply with a blank email with "Remove" as the subject. Since that time, however, I have nourished that 13% strength into a good 30-35% tolerance for inbox melodramatics.
Resisting the urge to respond to personal emails with "remove" or "unsubscribe" has been the gauge I use to measure my humanity.
I think I'm doing well.